Letter to the Editor
Naphyrone: Analytical profile of the new “legal high” substitute for mephedrone

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Conflict of Interest

The authors have no conflict of interest to declare.

References (5)

  • Consideration of the cathinones

    (June 2010)
  • Daily Mail

    Teenager dies after experimenting with legal drug meow meow

    (21 January 2010)
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    The drug has several street names, such as for example “MMCat”, “MMC hammer”, “Meow/Miaow”, “Meph”, “Bubles”, “Fiskrens”, “Ronzio”, “Crab”, “Diablo XXX” and “Blow” [15,17]. When mephedrone was made a controlled drug in the United Kingdom in April 2010, naphyrone (naphthylpyrovalerone; “Energy-1”, “NRG-1”, “Rave”) appeared on the market as its legal alternative [8,18,19]. MDPV (3,4-methylenedioxypyrovalerone; “Magic”, “Maddie”, “Black Rob”, “Super Coke”, “PV”, “Cloud9”, “Powdered Rush” or “White Horse”) was first detected in Japan in 2006, in Germany in 2007, in Finland in 2008, in the United Kingdom and in Poland after the ban on mephedrone [6,8,18,20–22].

  • Screening approach, optimisation and scale-up for chiral liquid chromatography of cathinones

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    After a number of adverse effects had been reported [8] it was ultimately banned in the UK, being designated as a Class B drug [9]. Surprisingly, despite the continuing interest in mephedrone [10] and related cathinones [11] and other drugs-of-abuse [12], little or no attention seemed to have been paid to the chiral nature of the molecule. While the cathinones were named after the original, natural source, the African plant Khat [13] they were prepared synthetically in clandestine laboratories as racemates.

  • Bath salts

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    With the ban on all analogues of synthetic cathinones in the United Kingdom, the only way to avoid prosecution for drug manufacturers is to explore substitutes that are not derivatives of cathinone. Naphyrone is one of these drugs but it was also banned in the United Kingdom as of July, 2010.41 In the latter half of 2010, other drug classes such as aminoindanes and benzofurans found their way into the legal high market.

  • Emerging drugs: A medicolegal insight

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