Journal of Forensic and Legal Medicine
Volume 16, Issue 3 , Pages 143-147 , April 2009

Chronic drug use confirmed by hair analysis: Its role in understanding both the medical cause of death and the circumstances surrounding the death

  • Sue Paterson, PhD (Consultant Forensic Toxicologist)

      Affiliations

    • Toxicology Unit, Imperial College London, Charing Cross Campus, St Dunstan’s Road, London W6 8RP, United Kingdom
    • Corresponding Author InformationCorresponding author.
  • ,
  • Rosa Cordero, BSc (Senior Toxicologist)

      Affiliations

    • Toxicology Unit, Imperial College London, Charing Cross Campus, St Dunstan’s Road, London W6 8RP, United Kingdom
  • ,
  • Elizabeth Stearns, MBBS, BDS (HM Coroner, Barrister)

      Affiliations

    • The Coroner’s Court, Queen’s Road, Walthamstow, London E17 8QP, United Kingdom

Received 13 February 2008 ,Revised 22 July 2008 ,Accepted 19 August 2008.

References 

  1. Kintz P, Villain M, Cirimele V. Hair analysis for drug detection. Ther Drug Monit. 2006;28:442–446
  2. Pragst F, Balikova MA. State of the art in hair analysis for detection of drug and alcohol abuse. Clin Chim Acta. 2006;370:17–49
  3. Mangin P. In:  Kintz P editors. Drug analyses in nonhead hair in Drug testing in hair. Ch:CRC Press; 1996;p. 279–287
  4. Kintz P. Value of hair analysis in post-mortem toxicology. Forensic Sci Int. 2004;142:127–134
  5. Kronstrand R, Grundin R, Jonsson J. Incidence of opiates, amfetamines and cocaine in hair and blood in fatal cases of heroin overdose. Forensic Sci Int. 1998;92:29–38
  6. Couper FJ, McIntyre IM, Drummer OH. Detection of antidepressant and antipsychotic-drugs in post-mortem human scalp hair. J Forensic Sci. 1995;40:87–90
  7. Cordero R, Paterson S. Simultaneous quantification of opiates, amfetamines, cocaine and metabolites and diazepam and metabolite in a single hair sample using GC–MS. J Chromatogr B. 2007;850:423–431
  8. Tagliaro F, De Battisti Z, Smith FP, Margio M. Death from heroin overdose: findings from hair analysis. Lancet. 1998;351(9120):1923–1925
  9. Gold MS, Jacobs WS. In:  Lowinson JH,  Ruiz P,  Millman RB,  Langrod JG editor. Cocaine and crack: clinical aspects in substance abuse. Philadelphia: Lippincott Williams and Wilkins; 2005;p. 218–252
  10. Bell L. On a form of disease resembling some advanced stages of mania and fever, but so contradistinguished from any ordinarily observed or described combination of symptoms as to render it probable that it may be an overlooked and hitherto unrecorded malady. Am J Insanity. 1849;6:97–127
  11. Wetli C, Fishbain D. Cocaine-induced psychosis and sudden death in recreational cocaine users. J Forensic Sci. 1985;30:873–880
  12. Wetli CV, Mash D, Karch SB. Cocaine-associated agitated delirium and the neuroleptic malignant syndrome. Am J Emerg Med. 1996;14:425–428
  13. Karch SB, Stephens BG. Relating cocaine blood concentrations to toxicity: an autopsy study of 99 cases. J Forensic Sci. 1998;43:41–45
  14. Ruttenber AJ, McAnally HB, Wetli CV. Cocaine-associated rhabdomyolysis and excited delirium: different stages of the same syndrome. AM J Forensci Med Pathol. 1999;20:120–127
  15. Karch SB. Pathology of drug abuse. Florida: CRC Press; 2002;p. 91–6
  16. Cairns T, Hill V, Schaffer M, Thistle W. Removing and identifying drug contamination in the analysis of human hair. Forensic Sci Int. 2004;145:97–108
  17. Kintz P, Brenneisen R, Bundeli P, Mangin P. Sweat testing for heroin and metabolites in a heroin maintenance program. Clin Chem. 1997;43(5):736–739
  18. Kacinko S, Barnes AJ, Schwilke EW, Cone EJ, Moolchan ET, Heustis MA. Disposition of cocaine and its metabolites in human sweat after controlled cocaine administration. Clin Chem. 2005;51(11):2085–2094
  19. Joseph RE, Oyler JM, Wstadik AT, Ohuoha C, Cone EJ. Drug testing with alternative matrices 1. Pharmacological effects and disposition of cocaine and cocaine in plasma, sebum, and stratum corneum. J Anal Toxicol. 1998;22:6–17
  20. Society of Hair Testing . Recommendations for hair testing in forensic cases. Forensic Sci Int. 2004;145:83–84
  21. Yegles M. Pitfalls in hair analysis: cosmetic treatment. Annal Toxicol Anal. 2005;XV11:275–278
  22. Konstrand R, Forstberg-Peterson S, Agedal BK, Ahlner J, Larson G. Codeine concentrations in hair after oral administration is dependent on melanin content. Clin Chem. 1999;45:1485–1494
  23. Uhl M, Scheufler F. Effects of hair color on the drug incorporation into human hair. Annal Toxicol Anal. 2005;XV11:279–284

PII: S1752-928X(08)00174-1

doi: 10.1016/j.jflm.2008.08.012

Journal of Forensic and Legal Medicine
Volume 16, Issue 3 , Pages 143-147 , April 2009