Journal of Forensic and Legal Medicine
Volume 14, Issue 7 , Pages 416-422 , October 2007

Interpretation of lesions of the cardiac conduction system in cocaine-related fatalities

Received 26 January 2007 ,Accepted 7 February 2007.

References 

  1. Chakko S, Myerburg RJ. Cardiac complications of cocaine abuse. Clin Cardiol. 1995;18(2):67–72
  2. Dressler FA, Malekzadeh S, Roberts WC. Quantitative analysis of amounts of coronary arterial narrowing in cocaine addicts. Am J Cardiol. 1990;65(5):303–308
  3. Fineschi V, Wetli CV, Di PM, Baroldi G. Myocardial necrosis and cocaine. A quantitative morphologic study in 26 cocaine-associated deaths. Int J Legal Med. 1997;110(4):193–198
  4. Karch SB, Green GS, Young S. Myocardial hypertrophy and coronary artery disease in male cocaine users. J Forensic Sci. 1995;40(4):591–595
  5. Karch SB, Billingham ME. Coronary artery and peripheral vascular disease in cocaine users. Coronary Artery Dis. 1995;6(3):220–225
  6. Kloner RA, Hale S, Alker K, Rezkalla S. The effects of acute and chronic cocaine use on the heart. Circulation. 1992;85(2):407–419
  7. Kloner RA, Rezkalla SH. Cocaine and the heart. New Engl J Med. 2003;348(6):487–488[comment]
  8. Knuepfer MM. Cardiovascular disorders associated with cocaine use: myths and truths. Pharmacol Therap. 2003;97(3):181–222
  9. Kringsholm B, Christoffersen P. Lung and heart pathology in fatal drug addiction. A consecutive autopsy study. Forensic Sci Int. 1987;34(1–2):39–51
  10. Rajs J, Falconer B. Cardiac lesions in intravenous drug addicts. Forensic Sci Int. 1979;13(3):193–209
  11. Rezkalla SH, Hale S, Kloner RA. Cocaine-induced heart diseases. Am Heart J. 1990;120(6 Pt 1):1403–1408
  12. Rump AF, Theisohn M, Klaus W. The pathophysiology of cocaine cardiotoxicity. Forensic Sci Int. 1995;71(2):103–115
  13. Virmani R, Robinowitz M, Smialek JE, Smyth DF. Cardiovascular effects of cocaine: an autopsy study of 40 patients. Am Heart J. 1988;115(5):1068–1076[see comment]
  14. Michaud K, Romain N, Taroni F, Horisberger B, Mangin P. Evaluation of a simplified method of the conduction system analysis in 110 forensic cases. Forensic Sci Int. 2002;130(1):13–24
  15. Winek CL, Wahba WW, Winek CL, Balzer TW. Drug and chemical blood-level data 2001. Forensic Sci Int. 2001;122(2–3):107–123
  16. Kitzman DW, Scholz DG, Hagen PT, Ilstrup DM, Edwards WD. Age-related changes in normal human hearts during the first 10 decades of life. Part II (Maturity): a quantitative anatomic study of 765 specimens from subjects 20 to 99 years old. Mayo Clin Proc. 1988;63(2):137–146
  17. Scholz DG, Kitzman DW, Hagen PT, Ilstrup DM, Edwards WD. Age-related changes in normal human hearts during the first 10 decades of life. Part I (Growth): A quantitative anatomic study of 200 specimens from subjects from birth to 19 years old. Mayo Clinic Proc. 1988;63(2):126–136[erratum appears in Mayo Clin Proc 1988 Jun;63(6):637]
  18. James TN. Normal variations and pathologic changes in structure of the cardiac conduction system and their functional significance. J Am Coll Cardiol. 1985;5(6 Suppl.):71B–8B
  19. Lev M, Bharati S. Lesions of the conduction system and their functional significance. Pathol Ann. 1974;9(0):157–207
  20. Cohle SD, Lie JT. Histopathologic spectrum of the cardiac conducting tissue in traumatic and noncardiac sudden death patients under 30 years of age: an analysis of 100 cases. Anat Pathol. 1998;3:53–76
  21. Bauman JL, Grawe JJ, Winecoff AP, Hariman RJ. Cocaine-related sudden cardiac death: a hypothesis correlating basic science and clinical observations. J Clin Pharmacol. 1994;34(9):902–911
  22. Krantz MJ, Rowan SB, Mehler PS. Cocaine-related torsade de pointes in a methadone maintenance patient. J Addict Dis. 2005;24(1):53–60
  23. Ortega-Carnicer J, Bertos-Polo J, Gutierrez-Tirado C. Aborted sudden death, transient Brugada pattern, and wide QRS dysrrhythmias after massive cocaine ingestion. J Electrocardiol. 2001;34(4):345–349
  24. Baughman KL. Diagnosis of Myocarditis: Death of Dallas Criteria. Circulation. 2006;113(4):593–595
  25. Dettmeyer R, Baasner A, Schlamann M, Padosch SA, Haag C, Kandolf R, et al. Role of virus-induced myocardial affections in sudden infant death syndrome: a prospective postmortem study. Pediatr Res. 2004;55(6):947–952
  26. Kuhl U, Pauschinger M, Bock T, Klingel K, Schwimmbeck CPL, Seeberg B, et al. Parvovirus B19 infection mimicking acute myocardial infarction. Circulation. 2003;108(8):945–950
  27. Clark JC, Milroy CM, Forrest ARW. Deaths from methadone use. J Clin Forensic Med. 1995;2(3):143–144
  28. Kornick CA, Kilborn MJ, Santiago-Palma J, Schulman G, Thaler HT, Keefe DL, et al. QTc interval prolongation associated with intravenous methadone. Pain. 2003;105(3):499–506
  29. Krantz MJ, Lowery CM, Martell BA, Gourevitch MN, Arnsten JH. Effects of methadone on QT-interval dispersion. Pharmacotherapy. 2005;25(11):1523–1529
  30. Drummer O, Forrest AR, Goldberger B, Karch SB. Forensic science in the dock. BMJ. 2004;329(7467):636–637
  31. Karch SB, Stephens BG. Toxicology and pathology of deaths related to methadone: retrospective review. Western J Med. 2000;172(1):11–14[see comment]
  32. Drummer OH. Postmortem toxicology of drugs of abuse. Forensic Sci Int. 2004;142(2–3):101–113
  33. Pounder DJ. The nightmare of postmortem drug changes. Legal Med. 1993;163–191
  34. Karch SB, Stephens BS. When is cocaine the cause of death?. Am J Forensic Med Pathol. 1991;12(1):1–2
  35. Stephens BG, Jentzen JM, Karch S, Mash DC, Wetli CV. Criteria for the interpretation of cocaine levels in human biological samples and their relation to the cause of death. Am J Forensic Med Pathol. 2004;25(1):1–10

PII: S1752-928X(07)00017-0

doi: 10.1016/j.jflm.2007.02.003

Journal of Forensic and Legal Medicine
Volume 14, Issue 7 , Pages 416-422 , October 2007

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