Journal of Forensic and Legal Medicine
Volume 14, Issue 8 , Pages 475-481 , November 2007

Forensic issues in Down syndrome fatalities

  • Roger W. Byard (MBBS, MD)

      Affiliations

    • Corresponding Author InformationTel.: +618 8303 5441; fax: +618 8303 4408.

Received 23 July 2006 ,Accepted 18 January 2007.

References 

  1. Frid C, Drott P, Lundell B, Rasmussen F, Annerén G. Mortality in Down’s syndrome in relation to congenital malformations. J Intellect Disabil Res. 1999;43:234–241
  2. Balarajan R, Donnan SPB, Adelstein AM. Mortality and cause of death in Down’s syndrome. J Epidem Commun Health. 1982;36:127–129
  3. Singer RB, Strauss D. Comparative mortality in mentally retarded patients in California, with and without Down’s syndrome, 1986–1991. J Insurance Med. 1997;29:172–184
  4. Tolksdorf M, Wiedemann H-R. Clinical aspects of Down’s syndrome from infancy to adult life. Hum Genet Suppl. 1981;2:3–31
  5. Jancar J, Speller CJ. Fatal intestinal obstruction in the mentally handicapped. J Intellect Disabil Res. 1994;38:413–422
  6. Khalid K, Al-Salamah SM. Spectrum of general surgical problems in the developmentally disabled adults. Saudi Med J. 2006;27:70–75
  7. Dupont A, Væth M, Vibebech P. Mortality and life expectancy of Down’s syndrome in Denmark. J Ment Defic Res. 1986;30:111–120
  8. Baird PA, Sadovnick AD. Causes of death to age 30 in Down syndrome. Am J Hum Genet. 1988;43:239–248
  9. Øster J, Mikkelsen M, Nielsen A. Mortality and life-table in Down’s syndrome. Acta Paediatr Scand. 1975;64:322–326
  10. Scholl T, Stein Z, Hansen H. Leukemia and other cancers, anomalies and infections as causes of death in Down’s syndrome in the United States during 1976. Develop Med Child Neurol. 1982;24:817–829
  11. Fryers T. Survival in Down’s syndrome. J Ment Defic Res. 1986;30:101–110
  12. Hunter AGW. Down syndrome. In:  Cassidy SB,  Allanson JE editor. Management of Genetic Syndromes. New York: Wiley-Liss; 2001;p. 103–129Ch. 7
  13. Yang Q, Rasmussen SA, Freidman JM. Mortality associated with Down’s syndrome in the USA from 1983 to 1997: a population based study. Lancet. 2002;359:1019–1025
  14. Hasle H, Clemmensen IH, Mikkelsen M. Risks of leukaemia and solid tumours in individuals with Down’s syndrome. Lancet. 2000;355:165–169
  15. Hermon C, Alberman E, Beral V, Swerdlow AJ. Mortality and cancer incidence in persons with Down’s syndrome, their parents and siblings. Ann Hum Genet. 2001;65:167–176
  16. Hill DA, Gridley G, Cnattingius S, Mellemkjaer L, Linet M, Adami H-O, et al. Mortality and cancer incidence among individuals with Down syndrome. Arch Intern Med. 2003;163:705–711
  17. Gatenby P, Tuck R, Andrews C, O’Neil R. Antiphospholipid antibodies and stroke in Down syndrome. Lupus. 2003;12:58–62
  18. Walters RM. Suicidal behaviour in severely mentally handicapped patients. Brit J Psychiatr. 1990;157:444–446
  19. Amanuel B, Byard RW. Accidental asphyxia in bed in severely disabled children. J Paediatr Child Health. 2000;36:66–68
  20. Byard RW. Sudden Death in Infancy, Childhood and Adolescence. 2nd ed.. Cambridge: Cambridge University Press; 2004;
  21. Krous HF, Beckwith JB, Byard RW, Rognum TO, Bajanowski T, et al. Sudden infant death syndrome (SIDS) and unclassified sudden infant deaths (USID): a definitional and diagnostic approach. Pediatrics. 2004;114:234–238
  22. Ogbuihi S, Zink P. Tödliche Lungenblutung bei komplexer pulmonaler Angiodysplasie in einem Fall von Mongolismus. Z Rechtsmed. 1988;101:255–263
  23. Carter G, Jancar J. Sudden death in the mentally handicapped. Psychol Med. 1984;14:691–695
  24. Stahl J, Santos LD, Byard RW. Coronary artery thromboembolism and unexpected death in childhood and adolescence. J Forensic Sci. 1995;40:599–601
  25. Chaney RH, Eyman RK, Miller CR. The relationship of congenital heart disease and respiratory infection mortality in patients with Down’s syndrome. J Ment Defic Res. 1985;29:23–27
  26. Chaney RH, Eyman RK, Miller CR. Comparison of respiratory mortality in the profoundly mentally retarded and in the less retarded. J Ment Defic Res. 1979;23:1–7
  27. O’Brien KF, Tate K, Zaharia ES. Mortality in a large southeastern facility for persons with mental retardation. Am J Ment Retard. 1991;95:397–403
  28. Strauss D, Eyman RK. Mortality of people with mental retardation in California with and without Down syndrome, 1986–1991. Am J Ment Retard. 1996;100:643–653
  29. Puri BK, Lekh SK, Langa A, Zaman R, Singh I. Mortality in a hospitalized mentally handicapped population: a 10-year survey. J Intellect Disabil Res. 1995;39:442–446
  30. McKee JR, Bodfish JW. Sudden expected death in epilepsy in adults with mental retardation. Am J Ment Retard. 2000;105:229–235
  31. Hungerford GD, Akkaraju V, Rawe SE, Young GF. Atlanto-occipital and atlanto-axial dislocations with spinal cord compression in Down’s syndrome: a case report and review of the literature. Br J Radiol. 1981;54:758–761
  32. Parfenchuck TA, Bertrand SL, Powers MJ, Drvaric DM, Pueschel SM, Roberts JM. Posterior occipitoatlantal hypermobility in Down syndrome: an analysis of 199 patients. J Pediatr Orthop. 1994;14:304–308
  33. Alvarez N, Rubin L. Atlantoaxial instability in adults with Down syndrome: a clinical and radiological survey. Appl Res Ment Retard. 1986;7:67–78
  34. Creutzig U, Ritter J, Vormoor J, Ludwig WD, Niemeyer C, Reinisch I, et al. Myelodysplasia and acute myelogenous leukemia in Down’s syndrome. A report of 40 children of the AML-BFM Study Group. Leukemia. 1996;10:1677–1686
  35. Rohde M, Banner J, Byard RW. Congenital lesions associated with airway narrowing respiratory distress and unexpected infant and early childhood death. Forensic Sci Med Pathol. 2005;1:91–96
  36. Mitchell RB, Call E, Kelly J. Diagnosis and therapy for airway obstruction in children with Down syndrome. Arch Otolaryngol Head Neck Surg. 2003;129:642–645
  37. Buchin PJ, Levy JS, Schullinger JN. Down’s syndrome and the gastrointestinal tract. J Clin Gastroenterol. 1986;8:111–114
  38. Byard RW, Couper RTL. Acute gastric dilatation and spastic quadraparesis. J Pediatr. 2001;139:166
  39. Roy A, Simon GB. Intestinal obstruction as a cause of death in the mentally handicapped. J Ment Defic Res. 1987;31:193–197
  40. Byard RW. Mechanisms of unexpected death in infants and young children following foreign body ingestion. J Forensic Sci. 1996;41:438–441

PII: S1752-928X(07)00009-1

doi: 10.1016/j.jflm.2007.01.001

Journal of Forensic and Legal Medicine
Volume 14, Issue 8 , Pages 475-481 , November 2007

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