Journal of Forensic and Legal Medicine
Volume 14, Issue 8 , Pages 456-460 , November 2007

Hemoglobin F in sudden infant death syndrome: A San Diego SIDS/SUDC Research Project report

  • Henry F. Krous, MD

      Affiliations

    • Rady Children’s Hospital and Health Center, 3020 Children’s Way, MC5007, San Diego, CA 92123, United States
    • University of California, San Diego School of Medicine, La Jolla, CA, United States
    • Corresponding Author InformationCorresponding author. Address: Rady Children’s Hospital and Health Center, 3020 Children’s Way, MC5007, San Diego, CA 92123, United States. Tel.: +1 858 966 5944; fax: +1 858 974 8087.
    • ,
  • Elisabeth A. Haas, MPH

      Affiliations

    • Rady Children’s Hospital and Health Center, 3020 Children’s Way, MC5007, San Diego, CA 92123, United States
    • ,
  • Amy E. Chadwick, BA

      Affiliations

    • Rady Children’s Hospital and Health Center, 3020 Children’s Way, MC5007, San Diego, CA 92123, United States
    • ,
  • Homeyra Masoumi, MD

      Affiliations

    • Rady Children’s Hospital and Health Center, 3020 Children’s Way, MC5007, San Diego, CA 92123, United States
    • ,
  • Christina Stanley, MD

      Affiliations

    • Office of the Chief Medical Examiner, San Diego County, San Diego, CA, United States
    • ,
  • Gary W. Perry, PhD

      Affiliations

    • Center for Complex Systems and Brain Sciences, Florida Atlantic University, Boca Raton, FL 33431, United States

Received 6 September 2006 ,Revised 21 November 2006 ,Accepted 21 November 2006.

References 

  1. Krous HF, Beckwith JB, Byard RW, et al. Sudden infant death syndrome and unclassified sudden infant deaths: A definitional and diagnostic approach. Pediatrics. 2004;114:234–238
  2. Jones KL, Krous HF, Nadeau J, Blackbourne B, Zielke HR, Gozal D. Vascular endothelial growth factor in the cerebrospinal fluid of infants who died of sudden infant death syndrome: evidence for antecedent hypoxia. Pediatrics. 2003;111:358–363
  3. Gillan JE, Curran C, E OR, Cahalane SF, Unwin AR. Abnormal patterns of pulmonary neuroendocrine cells in victims of sudden infant death syndrome. Pediatrics. 1989;84:828–834
  4. Perrin DG, McDonald TJ, Cutz E. Hyperplasia of bombesin-immunoreactive pulmonary neuroendocrine cells and neuroepithelial bodies in sudden infant death syndrome. Pediatr Pathol. 1991;11:431–447
  5. Zielke HR, Krause BL. Activity of 5 enzymes and fetal hemoglobin in RBC of infants dying from the sudden infant death syndrome. In: Proc of Federation 1982, p. 1148.
  6. Zielke HR, Meny RG, O’Brien MJ, et al. Normal fetal hemoglobin levels in the sudden infant death syndrome. N Engl J Med. 1989;321:1359–1364
  7. Fagan DG, Walker A. Haemoglobin F levels in sudden infant deaths. Br J Haematol. 1992;82:422–430
  8. Gilbert-Barness E, Kenison K, Carver J. Fetal hemoglobin and sudden infant death syndrome. Arch Pathol Lab Med. 1993;117:177–179
  9. Perry GW, Vargas-Cuba R, Vertes RP. Fetal hemoglobin levels in sudden infant death syndrome. Arch Pathol Lab Med. 1997;121:1048–1054
  10. Giulian GG, Gilbert EF, Moss RL. Elevated fetal hemoglobin levels in sudden infant death syndrome. N Engl J Med. 1987;316:1122–1126
  11. Cheron G, Bachoux I, Maier M, Massonneau M, Peltier JY, Girot R. Fetal hemoglobin in sudden infant death syndrome. N Engl J Med. 1989;320:1011–1012
  12. Kline CA, Ellerbrook RC, Goldstein DE, Monzon CM, Hillman LS. Measurement of fetal hemoglobin (HbF) in sudden infant death syndrome (SIDS) and controls using radial immunodiffusion (RID) and high pressure liquid chromatography (HPLC). Pediatr Res. 1989;25:270A
  13. Willinger M, James LS, Catz C. Defining the sudden infant death syndrome (SIDS): deliberations of an expert panel convened by the National Institute of Child Health and Human Development. Pediatr Pathol. 1991;11:677–684
  14. Beckwith JB. Discussion of terminology and definition of the sudden infant death sydrome. In:  Bergman AB,  Beckwith JB,  Ray CG editor. Proceedings of the Second International Conference on the Causes of Sudden Death in Infants. Seattle: University of Washington Press; 1970;p. 14–22
  15. Vertes RP, Perry GW. Sudden infant death syndrome: a theory. Neurosci Biobehav Rev. 1993;17:305–312
  16. Gilbert EF, Kenison K. Fetal hemoglobin levels in SIDS. [letter; comment] N Engl J Med. 1990;323:1281–1282
  17. Krous HF, Byard RW. International standardized autopsy protocol for sudden unexpected infant death. Appendix I. In:  Byard RW,  Krous HF editor. Sudden infant death syndrome: Problems, Progress and Possibilities. London: Arnold; 2001;p. 319–333
  18. CDC. Sudden, Unexplained Infant Death Initiative Reporting Form (SUIDIRF). Available from: http://www.cdc.gov/SIDS/PDF/SUIDIforms.pdf.
  19. Betke K, Marti HR, Schlicht I. Estimation of small percentages of foetal haemoglobin. Nature. 1959;184:1877–1878
  20. Pembry ME, McWade P, Weatherall DJ. Reliable routine estimation of small amounts of foetal haemoglobin by alkali denaturation. J Clin Pathol. 1972;25:738–740

PII: S1752-928X(07)00003-0

doi: 10.1016/j.jflm.2006.11.005

Journal of Forensic and Legal Medicine
Volume 14, Issue 8 , Pages 456-460 , November 2007

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