Journal of Forensic and Legal Medicine
Volume 14, Issue 5 , Pages 270-274 , July 2007

Immunohistochemical distribution of cyclic nucleotide phosphodiesterase (PDE) isoenzymes in the human vagina: A potential forensic value?

  • Knut Albrecht, MD (Physician)

      Affiliations

    • Hannover Medical School, Deparment of Legal Medicine, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany
    • Corresponding Author InformationCorresponding author. Tel.: +49 511 532 4569, fax: +49 511 532 4569.
    • ,
  • Stefan Ückert, PhD (Scientist)

      Affiliations

    • Hanover Medical School, Department of Urology, Hannover, Germany
    • ,
  • Matthias Oelke, MD (Physician)

      Affiliations

    • University of Amsterdam, Academic Medical Center (AMC), Department of Urology, Amsterdam, The Netherlands
    • ,
  • Karl-Erik Andersson, PhD (Professor of Pharmacology)

      Affiliations

    • Lund University Hospital, Department of Clinical and Experimental Pharmacology, Lund, Sweden
    • ,
  • Udo Jonas, MD, PhD (Professor of Urology)

      Affiliations

    • University of Amsterdam, Academic Medical Center (AMC), Department of Urology, Amsterdam, The Netherlands
    • ,
  • Hans-Dieter Tröger, MD, PhD (Professor of Legal Medicine)

      Affiliations

    • Hannover Medical School, Deparment of Legal Medicine, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany
    • ,
  • Petter Hedlund, PhD (Professor of Pharmacology)

      Affiliations

    • Lund University Hospital, Department of Clinical and Experimental Pharmacology, Lund, Sweden

Received 30 September 2005 ,Revised 21 July 2006 ,Accepted 10 August 2006.

References 

  1. Wiegmann H. Über den Glykogengehalt der Scheidenepithelien und seine diagnostische Bedeutung. Thesis, Faculty of Medicine, Ludwig-Maximilians-University, Munich, Germany; 1910.
  2. Merkel H. Über den Glykogengehalt des Scheidenepithels, seine diagnostische Bedeutung und deren kritische Bewertung. Z Ges Gerichtl Med. 1924;4:1
  3. Conti M, Jin SL. The molecular biology of cyclic nucleotide phosphodiesterases. Prog Nucleic Acid Res Mol Biol. 1999;63:1–38
  4. Soderling SH, Beavo JA. Regulation of cAMP and cGMP signaling: new phosphodiesterases and new functions. Curr Opin Cell Biol. 2000;12:174–179
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  11. Baechtel FS, Comey CT. Applications of molecular biology to analysis of forensic evidence. Biologicals. 1996;24:201–205
  12. Forsberg JG. A morphologist’s approach to the vagina. Acta Obstet Gynecol Scand Suppl. 1996;163:3–10
  13. Ückert S, Hedlund P, Bogun Y, Stief CG, Truss MC, Jonas U, et al. Immunohistochemical presence of cyclic AMP- and cyclic GMP-phosphodiesterase isoenzymes in the human clitoris. Eur Urol. 2003;1(Suppl. 2):118;Abstract
  14. Park K, Moreland RB, Goldstein I, Atala A, Traish A. Sildenafil inhibits phosphodiesterase type 5 in human clitoral corpus cavernosum smooth muscle. Biochem Biophys Res Comm. 1998;49:612–617
  15. Traish A, Moreland RB, Huang YH, Kim NN, Berman J, Goldstein I. Development of human and rabbit vaginal smooth muscle cell cultures: effects of vasoactive agents on intracellular levels of cyclic nucleotides. Mol Cell Biol Res Commun. 1999;2:131–137
  16. D’Amati G, Di Gioia CRT, Giordano D, Giorgi M, Dolci S, Jannini EA. Type 5 phosphodiesterase expression in the human vagina. Urology. 2002;60:191–195
  17. Chujor CS, Hammerschmid F, Lam C. Cyclic nucleotide phosphodiesterase 4 subtypes are differentially expressed by primary keratinocytes and human epidermoid cell lines. J Invest Dermatol. 1998;110:287–291
  18. Chan SC, Reifsnyder D, Beavo JA, Hanifin JM. Immunochemical characterization of the distinct monocyte cyclic AMP-phosphodiesterase from patients with atopic dermatitis. J Allergy Clin Immunol. 1993;91:1179–1188
  19. Delgado M, Fuentes JA, Fernandez-Alfonso MS. Histamine up-regulates phosphodiesterase IV activity in U-937 cells through H2 receptor stimulation and cAMP increase. Med Sci Monit. 2003;9:BR212–BR219
  20. Ückert S, Ellinghaus P, Albrecht K, Stief CG, Bischoff E, Jonas U. Expression of messenger RNA (mRNA) encoding for different phosphodiesterase (PDE) isoenzymes in human vaginal tissue. J Sex Med. 2004;2(Suppl 1):29;Abstract

PII: S1353-1131(06)00190-8

doi: 10.1016/j.jcfm.2006.08.010

Journal of Forensic and Legal Medicine
Volume 14, Issue 5 , Pages 270-274 , July 2007

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